Chronic Fatigue Syndrome/Myalgic Encephalomyelitis is a complicated disorder characterized by extreme fatigue that lasts for at least six months (in many instances, years) and that cannot be fully explained by an underlying medical condition. Chronic Fatigue Syndrome characteristically worsens with physical or mental activity, but does not improve with rest which places a significant amount of difficulty on performing one's activities of daily living  

Chronic fatigue like most chronic illnesses can be attributed to a wide range of potential mechanisms. There is no definitive diagnostic testing or criteria for Chronic Fatigue Syndrome, leading to variations in treatment approaches and a lack of consistent guidelines  for patients. With that being said management of Chronic Fatigue Syndrome SHOULD be highly individualized  as the condition will vary greatly from person to person and personalized medicine is not what the traditional western medicine model is great at.